Updating on dental implant osseointegration and survival rate in osteoporotic bone

  • Nike Hendrijantini Airlangga University
  • Mefina Kuntjoro Airlangga University
  • Bambang Agustono Airlangga University
  • Alvin Phen Airlangga University
  • Anisa Catteleya Nur Sya’bani Airlangga University
Keywords: survival rate, osseointegration, dental implants, osteoporosis

Abstract

Background: Systemic diseases may impact osseointegration of dental implants. Osteoporosis has become one of the concerning diseases since its prevalence reached 18.3% in the world and 10.3% in Indonesia. It is characterized by the decrease in bone thickness, alteration of trabecular structures, and increase in ratio of carbonate and phosphate, making the bone more fragile and prone to fracture. Consequently, the issue of bone quantity and quality will have a great impact on dental implant survival rate.Objectives: To know the effect of osteoporosis on survival rate and osseointegration of dental implants.Conclusion: Dentists should be more cautious if patients receiving dental implant treatment have a bone mineral density (BMD) score of -2.5 <  T-Score < -1 and an estrogen deficiency, because both are directly related to osteoporosis. Consumption of bisphosphonates should also be asked because it could cause osteonecrosis of the jaw. Most studies show no significant differences between survival rate of implants placed on osteoporotic patients and healthy patients after a short time period (0-1 year). However, most studies show significant differences after a long time period (5-7 years) so evaluation of implants is recommended.

Author Biographies

Nike Hendrijantini, Airlangga University
Department of Prosthodontics, Faculty of Dental Medicine, Airlangga University,Surabaya – Indonesia.
Mefina Kuntjoro, Airlangga University
Department of Prosthodontics, Faculty of Dental Medicine, Airlangga University,Surabaya – Indonesia.
Bambang Agustono, Airlangga University
Department of Prosthodontics, Faculty of Dental Medicine, Airlangga University,Surabaya – Indonesia.
Alvin Phen, Airlangga University
Undergraduate Student of the Faculty of Dental Medicine, Airlangga University, Surabaya – Indonesia.
Anisa Catteleya Nur Sya’bani, Airlangga University
Undergraduate Student of the Faculty of Dental Medicine, Airlangga University, Surabaya – Indonesia.

References

Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D. The Effects of Systemic Diseases and Medications on Implant Osseointegration: A Systematic Review. International Journal of Oral & Maxillofacial Implants. 2019 Jan 2;34.

Salari N, Ghasemi H, Mohammadi L, Rabieenia E, Shohaimi S, Mohammadi M. The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis. Journal of orthopaedic surgery and research. 2021 Dec;16(1):1-20.

Kemenkes RI. Infodatin: Situasi Osteoporosis Di Indonesia. Kementerian Kesehatan Republik Indonesia. 2020.

Gibreel, S., Mohamed, H.G., Suraj, A.R. and Anil, S., 2021. Osseointegration of Dental Implants and Osteoporosis. In Current Concepts in Dental Implantology-From Science to Clinical Research. IntechOpen.

Bover J, Ureña-Torres P, Torregrosa JV, Rodríguez-García M, Castro-Alonso C, Górriz JL, Alonso AM, Cigarrán S, Benito S, López-Báez V, Cora MJ. Osteoporosis, bone mineral density and CKD–MBD complex (I): Diagnostic considerations. Nefrología (English Edition). 2018 Sep 1;38(5):476-90.

Limbong EA, Syahrul F. Rasio Risiko Osteoporosis Menurut Indeks Massa Tubuh, Paritas, dan Konsumsi Kafein. Jurnal Berkala Epidemiologi. 2015;3(2):194-204.

McNamara LM. Osteocytes and Estrogen Deficiency. Current osteoporosis reports. 2021 Nov 26:1-2.

Gbadebo OS, Lawal FB, Sulaiman AO, Ajayi DM. Dental implant as an option for tooth replacement: The awareness of patients at a tertiary hospital in a developing country. Contemporary Clinical Dentistry. 2014 Jul 1;5(3):302–6.

Shemtov-Yona K, Rittel D. An Overview of the Mechanical Integrity of Dental Implants. Vol. 2015, BioMed Research International. Hindawi Publishing Corporation; 2015.

Misch CE, Perel ML, Wang HL, Sammartino G, Galindo-Moreno P, Trisi P, et al. Implant success, survival, and failure: The International Congress of Oral Implantologists (ICOI) pisa consensus conference. Implant Dentistry. 2008;17(1):5–15.

Dutta, S.R., Passi, D., Singh, P., Atri, M., Mohan, S. and Sharma, A., 2020. Risks and complications associated with dental implant failure: Critical update. National Journal of Maxillofacial Surgery, 11(1), p.14.

Hendrijanti, N., Rostiny, R., Kuntjoro, M., Hidajati, H.E., Soekobagiono, S., Subianto, A., Ariani, M.D. and Bakhtiar, D.A., 2019. The effect of low-level estrogen in mandibular bone: An in vivo study. Dental Research Journal, 16(2), p.65.

Föger-Samwald, U., Dovjak, P., Azizi-Semrad, U., Kerschan-Schindl, K. and Pietschmann, P., 2020. Osteoporosis: pathophysiology and therapeutic options. EXCLI journal, 19, p.1017.

Barnsley J, Buckland G, Chan PE, Ong A, Ramos AS, Baxter M, Laskou F, Dennison EM, Cooper C, Patel HP. Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people. Aging clinical and experimental research. 2021 Apr;33(4):759-73.

Kranioti EF, Bonicelli A, García-Donas JG. Bone-mineral density: clinical significance, methods of quantification and forensic applications. Research and Reports in Forensic Medical Science. 2019 Jul 25(9):9-21.

Siris E, Adler R, Bilezikian J et al. The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group. Osteoporosis International. 2014; 25(5): 1439-1443.

Ho-Pham L, Nguyen N, Nguyen T. Quantification of the relative contribution of estrogen to bone mineral density in men and women. BMC Musculoskeletal Disorders. 2013; 14: p.366.

Aspray TJ, Hill TR. Osteoporosis and the aging skeleton. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019:453-76

Watanabe PC, Rodrigues GA, Azenha MR, Ribeiro MC, de Almeida Souza Filho E, Vieira RA, Bottacin FS. Bone Quality of the Dento-Maxillofacial Complex and Osteoporosis. Opportunistic Radiographic Interpretation. In Osteoporosis-Recent Advances, New Perspectives and Applications 2021 Mar 12. IntechOpen.

Siebert T, Jurkovic R, Statelova D, Strecha J. Immediate implant placement in a patient with osteoporosis undergoing bisphosphonate therapy: 1-year preliminary prospective study. Journal of Oral Implantology. 2015 Jul;41(S1):360-5.

Block MS. Dental Implants: The Last 100 Years. Journal of Oral and Maxillofacial Surgery. 2018 Jan 1;76(1):11–26.

Rangarajan V, Padmanabhan TV. Textbook of Prosthodontics-E Book. Elsevier Health Sciences; 2017 Jul 18.

Temmerman A, Rasmusson L, Kübler A, Thor A, Quirynen M. An open, prospective, non‐randomized, controlled, multicentre study to evaluate the clinical outcome of implant treatment in women over 60 years of age with osteoporosis/osteopenia: 1‐year results. Clinical oral implants research. 2017 Jan;28(1):95-102.

Trajanoska K, Rivadeneira F. The genetic architecture of osteoporosis and fracture risk. Bone. 2019 Sep 1;126:2-10.

Merheb J, Temmerman A, Rasmusson L, Kübler A, Thor A, Quirynen M. Influence of Skeletal and Local Bone Density on Dental Implant Stability in Patients with Osteoporosis. Clin Implant Dent Relat Res. 2016 Apr;18(2):253-60.

Holahan CM, Wiens JL, Weaver A, Assad D, Koka S. Relationship between systemic bone mineral density and local bone quality as effectors of dental implant survival. Clinical implant dentistry and related research. 2011 Mar;13(1):29-33.

Niedermaier R, Stelzle F, Riemann M, Bolz W, Schuh P, Wachtel H.

Implant‐supported immediately loaded fixed full‐arch dentures: evaluation of implant survival rates in a case cohort of up to 7 years. Clinical Implant Dentistry and Related Research. 2017 Feb;19(1):4-19.

Temmerman A, Rasmusson L, Kübler A, Thor A, Merheb J, Quirynen M. A prospective, controlled, multicenter study to evaluate the clinical outcome of implant treatment in women with osteoporosis/osteopenia: 5-year results. Journal of dental research. 2019 Jan;98(1):84-90.

Alsaadi W, AbouSulaiman A, Monzer AlSabbagh M, Alsadi W. Retrospective Study Of Dental Implants Survival Rate In Postmenopausal Women With Osteoporosis. Int J Dentistry Oral Sci. 2021;8(9):4259–66.

Corcuera-Flores JR, Alonso-Domínguez AM, Serrera-Figallo MÁ,

Torres-Lagares D, Castellanos-Cosano L, Machuca-Portillo G. Relationship Between Osteoporosis and Marginal Bone Loss in Osseointegrated Implants: A 2-Year Retrospective Study. Journal of Periodontology. 2016 Jan;87(1):14–20.

Li Y, He S, Hua Y, Hu J. Effect of osteoporosis on fixation of osseointegrated implants in rats. Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2017 Nov 1;105(8):2426–32.

Lotz EM, Cohen DJ, Ellis RA, Wayne JS, Schwartz Z, Boyan BD. Ibandronate Treatment Before and After Implant Insertion Impairs Osseointegration in Aged Rats with Ovariectomy Induced Osteoporosis. JBMR Plus. 2019 Jul 1;3(7)

Chen X, Moriyama Y, Takemura Y, Rokuta M, Ayukawa Y. Influence of osteoporosis and mechanical loading on bone around osseointegrated dental implants: A rodent study. Journal of the mechanical behavior of biomedical materials. 2021 Nov 1;123.

Liu XL, Li CL, Lu WW, Cai WX, Zheng LW. Skeletal site-specific response to ovariectomy in a rat model: change in bone density and microarchitecture. Clinical Oral Implants Research. 2015 Apr 1;26(4):392–8

Meng HW, Chien EY, Chien HH. Dental implant bioactive surface

modifications and their effects on osseointegration: a review. Biomarker research. 2016;4(1).

Zhang C, Zhang T, Geng T, Wang X, Lin K, Wang P. Dental Implants Loaded With Bioactive Agents Promote Osseointegration in Osteoporosis: A Review. Vol. 9, Frontiers in Bioengineering and Biotechnology. Frontiers Media S.A.; 2021.

Lin G, Zhou C, Lin M, Xu A, He F. Strontium-incorporated titanium implant surface treated by hydrothermal reactions promotes early bone osseointegration in osteoporotic rabbits. Clinical oral implants research. 2019;30(8):777–90.

al Mugeiren OM, Baseer MA. Dental Implant Bioactive Surface Modifiers: An Update. Journal of International Society of Preventive & Community Dentistry. 2019 Jan 1;9(1):5–12.

Hendrijantini N, Kusumaningsih T, Rostiny R, Mulawardhana P, Danudiningrat CP, Rantam FA. A potential therapy of human umbilical cord mesenchymal stem cells for bone regeneration on osteoporotic mandibular bone. European Journal of Dentistry. 2018 Jul 1;12(3):358.

Yin L, Zhou ZX, Shen M, Chen N, Jiang F, Wang SL. The Human Amniotic Mesenchymal Stem Cells (hAMSCs) Improve the Implant Osseointegration and Bone Regeneration in Maxillary Sinus Floor Elevation in Rabbits. Stem Cells International. 2019;2019

Feng Y, Jiang Z, Zhang Y, Miao X, Yu Q, Xie Z, et al. Stem-cell-derived ECM sheet-implant complexes for enhancing osseointegration. Biomaterials science. 2020 Dec 7;8(23):6647–56.

Published
2022-06-01
Section
Articles